Nattokinase It’s an all natural potent enzyme that is extracted from natto and highly purified. nacho is a fermented soybean food that has been consumed in Japan for over a thousand years. Nattokinase has been the subject of many studies including human and animal trials. In 1980, researchers discovered thatNattokinase demonstrated a positive effect on blood flow in vitro. Nattokinase may also support cardiovascular health.